CATH Domain 4gtsA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.25	Alpha Horseshoe
	1.25.40	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
	1.25.40.120	Protein prenylyltransferase

Domain Context

CATH Clusters

Superfamily	Protein prenylyltransferase
Functional Family	Geranylgeranyl transferase type-2 subunit alpha

Enzyme Information

2.5.1.60

Protein geranylgeranyltransferase type II.

based on mapping to UniProt Q08602

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl- protein + diphosphate.

-!- This enzyme, along with EC 2.5.1.58 and EC 2.5.1.59, constitutes the protein prenyltransferase family of enzymes. -!- Attaches geranylgeranyl groups to two C-terminal cysteines in Ras- related GTPases of a single family, the Rab family (Ypt/Sec4 in lower eukaryotes) that terminate in XXCC, XCXC and CCXX motifs. -!- Reaction is entirely dependent on the Rab substrate being bound to Rab escort protein (REP). -!- Post-translational modification with the geranylgeranyl moiety is essential for Rab GTPases to be able to control the processes of membrane docking and fusion.

UniProtKB Entries (1)

Q08603

PGTB2_RAT

Rattus norvegicus

Geranylgeranyl transferase type-2 subunit beta

PDB Structure

PDB	4GTS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Development of Selective, Potent RabGGTase Inhibitors Stigter, E.A., Guo, Z., Bon, R.S., Wu, Y.W., Choidas, A., Wolf, A., Menninger, S., Waldmann, H., Blankenfeldt, W., Goody, R.S. J.Med.Chem.