CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.640 | Aspartate Aminotransferase; domain 2 |
|
3.40.640.10 | Type I PLP-dependent aspartate aminotransferase-like (Major domain) |
Domain Context
CATH Clusters
| Superfamily | Type I PLP-dependent aspartate aminotransferase-like (Major domain) |
| Functional Family |
Enzyme Information
| 2.6.1.7 |
Kynurenine--oxoglutarate transaminase.
based on mapping to UniProt Q8N5Z0
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
-!- Also acts on 3-hydroxykynurenine. -!- The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
|
| 2.6.1.39 |
2-aminoadipate transaminase.
based on mapping to UniProt Q8N5Z0
L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.
|
UniProtKB Entries (1)
| Q8N5Z0 |
AADAT_HUMAN
Homo sapiens
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
|
PDB Structure
| PDB | 4GDY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Discovery of Hydroxamate Bioisosteres as KATII Inhibitors with Improved Oral Bioavailability and Pharmacokinetics
MEDCHEMCOMM
|
