CATH Domain 4ga6A03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1030	Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2
	3.40.1030.10	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain

Domain Context

CATH Clusters

Superfamily	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
Functional Family	AMP phosphorylase

Enzyme Information

2.4.2.57

AMP phosphorylase.

based on mapping to UniProt Q5JCX3

(1) AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate. (2) CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate. (3) UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.

-!- The enzyme from archaea is involved in AMP metabolism and CO(2) fixation through type III RubisCO enzymes. -!- The activity with CMP and UMP requires activation by cAMP.

UniProtKB Entries (1)

Q5JCX3

AMPPA_THEKO

Thermococcus kodakarensis KOD1

AMP phosphorylase

PDB Structure

PDB	4GA6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure analysis of archaeal AMP phosphorylase reveals two unique modes of dimerization Nishitani, Y., Aono, R., Nakamura, A., Sato, T., Atomi, H., Imanaka, T., Miki, K. J.Mol.Biol.