CATH Classification
Level | CATH Code | Description |
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2 | Mainly Beta |
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2.40 | Beta Barrel |
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2.40.270 | Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; Domain 6 |
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2.40.270.10 | DNA-directed RNA polymerase, subunit 2, domain 6 |
Domain Context
CATH Clusters
Superfamily | DNA-directed RNA polymerase, subunit 2, domain 6 |
Functional Family |
Enzyme Information
2.7.7.6 |
DNA-directed RNA polymerase.
based on mapping to UniProt Q8RQE9
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.
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UniProtKB Entries (1)
Q8RQE9 |
RPOB_THET8
Thermus thermophilus HB8
DNA-directed RNA polymerase subunit beta
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PDB Structure
PDB | 4G7Z |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural basis of transcription initiation.
Science
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