CATH Domain 4g4eA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.20	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
	3.60.20.10	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1

Domain Context

CATH Clusters

Superfamily	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Functional Family	ATP-dependent protease subunit HslV

Enzyme Information

3.4.25.2

HslU--HslV peptidase.

based on mapping to UniProt P0A7B8

ATP-dependent cleavage of peptide bonds with broad specificity.

-!- The HslU subunit of the HslU--HslV complex functions as an ATP dependent 'unfoldase'. -!- The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. -!- HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. -!- Belongs to peptidase family T1.

UniProtKB Entries (1)

P0A7B8

HSLV_ECOLI

Escherichia coli K-12

ATP-dependent protease subunit HslV

PDB Structure

PDB	4G4E
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Alteration in the Pore Motif of the Bacterial 20S Proteasome Homolog HslV Leads to Uncontrolled Protein Degradation Park, E., Lee, J.W., Yoo, H.M., Ha, B.H., An, J.Y., Jeon, Y.J., Seol, J.H., Eom, S.H., Chung, C.H. J.Mol.Biol.