CATH Classification

Domain Context

CATH Clusters

Superfamily Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family Thymidylate synthase

Enzyme Information

2.1.1.45
Thymidylate synthase.
based on mapping to UniProt P9WFR9
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

P9WFR9
TYSY_MYCTU
Mycobacterium tuberculosis H37Rv
Thymidylate synthase ThyA

PDB Structure

PDB 4FOX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: Insights into the selectivity and mode of inhibition
Reddy, M.C.M., Bruning, J.B., Sacchettini, J.C., Harshbarger, W.
To be Published