CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.100 |
Domain Context
CATH Clusters
| Superfamily | 3.30.70.100 |
| Functional Family |
Enzyme Information
| 1.14.99.48 |
Heme oxygenase (staphylobilin-producing).
based on mapping to UniProt Q7A827
(1) Protoheme + 5 reduced acceptor + 4 O(2) = 5-oxo-delta-bilirubin + Fe(2+) + formaldehyde + 5 acceptor + 4 H(2)O. (2) Protoheme + 5 reduced acceptor + 4 O(2) = 15-oxo-beta-bilirubin + Fe(2+) + formaldehyde + 5 acceptor + 4 H(2)O.
-!- This enzyme, which is found in some pathogenic bacteria, is involved in an iron acquisition system that catabolizes the host's hemoglobin. -!- The two enzymes from the bacterium Staphylococcus aureus, encoded by the isdG and isdI genes, produce 67.5 % and 56.2 % delta- staphylobilin, respectively.
|
UniProtKB Entries (1)
| Q7A827 |
HDOX2_STAAN
Staphylococcus aureus subsp. aureus N315
Heme oxygenase (staphylobilin-producing) 2
|
PDB Structure
| PDB | 4FNH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Inactivation of the heme degrading enzyme IsdI by an active site substitution that diminishes heme ruffling.
J.Biol.Chem.
|