CATH Domain 4fm8A02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.70	Cathepsin D, subunit A; domain 1
	2.40.70.10	Acid Proteases

Domain Context

CATH Clusters

Superfamily	Acid Proteases
Functional Family	Beta-secretase 1

Enzyme Information

3.4.23.46

Memapsin 2.

based on mapping to UniProt P56817

Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu- Phe in the Swedish variant of Alzheimer's amyloid precursor protein.

-!- Suggested to be the major 'beta-secretase' responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. -!- Belongs to peptidase family A1.

UniProtKB Entries (1)

P56817

BACE1_HUMAN

Homo sapiens

Beta-secretase 1

PDB Structure

PDB	4FM8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Spirocyclic sulfamides as beta-secretase 1 (BACE-1) inhibitors for the treatment of Alzheimer's disease: utilization of structure based drug design, WaterMap, and CNS penetration studies to identify centrally efficacious inhibitors. Brodney, M.A., Barreiro, G., Ogilvie, K., Hajos-Korcsok, E., Murray, J., Vajdos, F., Ambroise, C., Christoffersen, C., Fisher, K., Lanyon, L., Liu, J., Nolan, C.E., Withka, J.M., Borzilleri, K.A., Efremov, I., Oborski, C.E., Varghese, A., O'Neill, B.T. J.Med.Chem.