CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.132 | Topoisomerase I; Chain A, domain 4 |
|
1.10.132.130 |
Domain Context
CATH Clusters
| Superfamily | 1.10.132.130 |
| Functional Family | Legumain preproprotein |
Enzyme Information
| 3.4.22.34 |
Legumain.
based on mapping to UniProt Q99538
Hydrolysis of proteins and small molecule substrates at -Asn-|- Xaa- bonds.
-!- Best known from legume seeds, the trematode Schistosoma mansoni and mammalian lysosomes. -!- Not inhibited by compound E-64. -!- Belongs to peptidase family C13.
|
UniProtKB Entries (1)
| Q99538 |
LGMN_HUMAN
Homo sapiens
Legumain
|
PDB Structure
| PDB | 4FGU |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation.
Proc.Natl.Acad.Sci.USA
|