CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.200 | Fumarase C; Chain A, domain 2 |
|
1.20.200.10 | Fumarase/aspartase (Central domain) |
Domain Context
CATH Clusters
| Superfamily | Fumarase/aspartase (Central domain) |
| Functional Family |
Enzyme Information
| 4.3.2.2 |
Adenylosuccinate lyase.
based on mapping to UniProt P30566
(1) N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP. (2) (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.
-!- Also acts on 1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5- aminoimidazole.
|
UniProtKB Entries (1)
| P30566 |
PUR8_HUMAN
Homo sapiens
Adenylosuccinate lyase
|
PDB Structure
| PDB | 4FFX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C ADSL Deficiency-Associated Mutation.
Biochemistry
|
