CATH Domain 4ff8A00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Tyrosine-protein kinase receptor TYRO3

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P55144

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P55144

TYRO3_MOUSE

Mus musculus

Tyrosine-protein kinase receptor TYRO3

PDB Structure

PDB	4FF8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase. Powell, N.A., Hoffman, J.K., Ciske, F.L., Kaufman, M.D., Kohrt, J.T., Quin, J., Sheehan, D.J., Delaney, A., Baxi, S.M., Catana, C., McConnell, P., Ohren, J., Perrin, L.A., Edmunds, J.J. Bioorg.Med.Chem.Lett.