CATH Domain 4falA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.100	NADP-dependent oxidoreductase domain

Domain Context

CATH Clusters

Superfamily	NADP-dependent oxidoreductase domain
Functional Family	Aldo-keto reductase family 1 member C3

Enzyme Information

1.1.1.188	Prostaglandin-F synthase. based on mapping to UniProt P42330 (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH. -!- Reduces prostaglandin D(2) and prostaglandin H(2) to prostaglandin F(2); prostaglandin D(2) is not an intermediate in the reduction of prostaglandin H(2). -!- Also catalyzes the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone.
1.1.1.112	Indanol dehydrogenase. based on mapping to UniProt P42330 Indan-1-ol + NAD(P)(+) = indanone + NAD(P)H. -!- 3(20)-alpha-hydroxysteroids are also oxidized, more slowly.
1.1.1.64	Testosterone 17-beta-dehydrogenase (NADP(+)). based on mapping to UniProt P42330 Testosterone + NADP(+) = androst-4-ene-3,17-dione + NADPH. -!- Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital.
1.-.-.-	Oxidoreductases. based on mapping to UniProt P42330
1.3.1.20	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. based on mapping to UniProt P42330 Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH.
1.1.1.239	3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)). based on mapping to UniProt P42330 Testosterone + NAD(+) = androstenedione + NADH. -!- Also acts on other 17-beta-hydroxysteroids, on the 3-alpha-hydroxy group of pregnanes and bile acids. -!- Different from EC 1.1.1.50 or EC 1.1.1.213. -!- Formerly EC 1.1.1.63.
1.1.1.357	3-alpha-hydroxysteroid 3-dehydrogenase. based on mapping to UniProt P42330 A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3-oxosteroid + NAD(P)H. -!- The enzyme acts on multiple 3-alpha-hydroxysteroids, such as androsterone and 5 alpha-dihydrotestosterone. -!- The mammalian enzymes are involved in inactivation of steroid hormones, while the bacterial enzymes are involved in steroid degradation. -!- This entry stands for enzymes whose stereo-specificity with respect to NAD(+) or NADP(+) is not known (cf. EC 1.1.1.50 and EC 1.1.1.213).

UniProtKB Entries (1)

AK1C3_HUMAN

Homo sapiens

Aldo-keto reductase family 1 member C3

PDB Structure

PDB	4FAL
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic acids; a New Class of Highly Potent and Selective Inhibitors of the Type 5 17-beta-hydroxysteroid Dehydrogenase AKR1C3 Jamieson, S.M., Brooke, D.G., Heinrich, D., Atwell, G.J., Silva, S., Hamilton, E.J., Turnbull, A.P., Rigoreau, L.J., Trivier, E., Soudy, C., Samlal, S.S., Owen, P.J., Schroeder, E., Raynham, T., Flanagan, J.U., Denny, W.A. J.Med.Chem.