CATH Domain 4f2vA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.572	Thymidylate Synthase; Chain A
	3.30.572.10	Thymidylate synthase/dCMP hydroxymethylase domain

Domain Context

CATH Clusters

Superfamily	Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family	Thymidylate synthase

Enzyme Information

2.1.1.45

Thymidylate synthase.

based on mapping to UniProt P0A884

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

TYSY_ECOLI

Escherichia coli K-12

Thymidylate synthase

PDB Structure

PDB	4F2V
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design of activated serine-containing catalytic triads with atomic-level accuracy. Rajagopalan, S., Wang, C., Yu, K., Kuzin, A.P., Richter, F., Lew, S., Miklos, A.E., Matthews, M.L., Seetharaman, J., Su, M., Hunt, J.F., Cravatt, B.F., Baker, D. Nat.Chem.Biol.