CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.572 | Thymidylate Synthase; Chain A | |
3.30.572.10 | Thymidylate synthase/dCMP hydroxymethylase domain |
Domain Context
CATH Clusters
Superfamily | Thymidylate synthase/dCMP hydroxymethylase domain |
Functional Family | Possible thymidylate synthase |
Enzyme Information
2.1.1.45 |
Thymidylate synthase.
based on mapping to UniProt P07607
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
|
UniProtKB Entries (1)
P07607 |
TYSY_MOUSE
Mus musculus
Thymidylate synthase
|
PDB Structure
PDB | 4EZ8 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal structures of complexes of mouse thymidylate synthase
crystallized with N4-OH-dCMP alone or in the presence of
N5,10-methylenetetrahydrofolate
Pteridines
|