CATH Classification

Domain Context

CATH Clusters

Superfamily Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family Possible thymidylate synthase

Enzyme Information

2.1.1.45
Thymidylate synthase.
based on mapping to UniProt P07607
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

P07607
TYSY_MOUSE
Mus musculus
Thymidylate synthase

PDB Structure

PDB 4EZ8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of complexes of mouse thymidylate synthase crystallized with N4-OH-dCMP alone or in the presence of N5,10-methylenetetrahydrofolate
Dowiercial, A., Jarmula, A., Rypniewski, W., Wilk, P., Kierdaszuk, B., Banaszak, K., Gorecka, K., Rode, W.
Pteridines