CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.10320 | LmbE-like |
Domain Context
CATH Clusters
| Superfamily | LmbE-like |
| Functional Family |
Enzyme Information
| 3.5.1.103 |
N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase.
based on mapping to UniProt P9WJN3
1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H(2)O = 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + acetate.
-!- This enzyme is considered the key enzyme and rate limiting step in the mycothiol biosynthesis pathway. -!- In addition to acetylase activity, the enzyme possesses weak mycothiol conjugate amidase activity, and shares sequence similarity with mycothiol S-conjugate amidase. -!- Formerly EC 3.1.1.n1.
|
UniProtKB Entries (1)
| P9WJN3 |
MSHB_MYCTU
Mycobacterium tuberculosis H37Rv
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase
|
PDB Structure
| PDB | 4EWL |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A new crystal form of MshB from Mycobacterium tuberculosis with glycerol and acetate in the active site suggests the catalytic mechanism.
Acta Crystallogr.,Sect.D
|
