CATH Domain 4er5A02

Superfamily	Vaccinia Virus protein VP39
Functional Family	Histone-lysine N-methyltransferase, H3 lysine-79 specific

2.1.1.43

Histone-lysine N-methyltransferase.

based on mapping to UniProt Q8TEK3

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

DOT1L_HUMAN

Homo sapiens

Histone-lysine N-methyltransferase, H3 lysine-79 specific

PDB	4ER5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Yu, W., Chory, E.J., Wernimont, A.K., Tempel, W., Scopton, A., Federation, A., Marineau, J.J., Qi, J., Barsyte-Lovejoy, D., Yi, J., Marcellus, R., Iacob, R.E., Engen, J.R., Griffin, C., Aman, A., Wienholds, E., Li, F., Pineda, J., Estiu, G., Shatseva, T., Hajian, T., Al-Awar, R., Dick, J.E., Vedadi, M., Brown, P.J., Arrowsmith, C.H., Bradner, J.E., Schapira, M. Nat Commun