CATH Domain 4er3A01

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.260	434 Repressor (Amino-terminal Domain)
	1.10.260.60

Superfamily	1.10.260.60
Functional Family	Histone-lysine N-methyltransferase, H3 lysine-79 specific

2.1.1.43

Histone-lysine N-methyltransferase.

based on mapping to UniProt Q8TEK3

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

DOT1L_HUMAN

Homo sapiens

Histone-lysine N-methyltransferase, H3 lysine-79 specific

PDB	4ER3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Yu, W., Chory, E.J., Wernimont, A.K., Tempel, W., Scopton, A., Federation, A., Marineau, J.J., Qi, J., Barsyte-Lovejoy, D., Yi, J., Marcellus, R., Iacob, R.E., Engen, J.R., Griffin, C., Aman, A., Wienholds, E., Li, F., Pineda, J., Estiu, G., Shatseva, T., Hajian, T., Al-Awar, R., Dick, J.E., Vedadi, M., Brown, P.J., Arrowsmith, C.H., Bradner, J.E., Schapira, M. Nat Commun