CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.260 | 434 Repressor (Amino-terminal Domain) | |
1.10.260.60 |
Domain Context
CATH Clusters
Superfamily | 1.10.260.60 |
Functional Family | Histone-lysine N-methyltransferase, H3 lysine-79 specific |
Enzyme Information
2.1.1.43 |
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q8TEK3
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
|
UniProtKB Entries (1)
Q8TEK3 |
DOT1L_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase, H3 lysine-79 specific
|
PDB Structure
PDB | 4ER0 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.
Nat Commun
|