CATH Domain 4eoxP00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.45	Peptide Deformylase
	3.90.45.10	Peptide deformylase

Domain Context

CATH Clusters

Superfamily	Peptide deformylase
Functional Family	Peptide deformylase

Enzyme Information

3.5.1.88

Peptide deformylase.

based on mapping to UniProt Q8DP79

Formyl-L-methionyl peptide + H(2)O = formate + methionyl peptide.

-!- Requires at least a dipeptide for an efficient rate of reaction. -!- N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. -!- Differs in substrate specificity from EC 3.5.1.27 and EC 3.5.1.31.

UniProtKB Entries (1)

Q8DP79

DEF_STRR6

Streptococcus pneumoniae R6

Peptide deformylase

PDB Structure

PDB	4EOX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Acylprolinamides: a new class of peptide deformylase inhibitors with in vivo antibacterial activity. Axten, J.M., Medina, J.R., Blackledge, C.W., Duquenne, C., Grant, S.W., Bobko, M.A., Peng, T., Miller, W.H., Pinckney, T., Gallagher, T.F., Kulkarni, S., Lewandowski, T., Van Aller, G.S., Zonis, R., Ward, P., Campobasso, N. Bioorg.Med.Chem.Lett.