1 keywords

CATH Domain 4emmE00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.226 2-enoyl-CoA Hydratase; Chain A, domain 1
Homologous Superfamily 3.90.226.10 2-enoyl-CoA Hydratase; Chain A, domain 1

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family ATP-dependent Clp protease proteolytic subunit

Enzyme Information

3.4.21.92
Endopeptidase Clp.
based on mapping to UniProt P63786
Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
-!- Belongs to peptidase family S14.

UniProtKB Entries (1)

P63786
CLPP_STAAW
Staphylococcus aureus subsp. aureus MW2
ATP-dependent Clp protease proteolytic subunit

PDB Structure

PDB 4EMM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Helix unfolding/refolding characterizes the functional dynamics of Staphylococcus aureus Clp protease
Ye, F., Zhang, J., Liu, H., Hilgenfeld, R., Zhang, R., Kong, X., Li, L., Lu, J., Zhang, X., Li, D., Jiang, H., Yang, C.-G., Luo, C.
J.Biol.Chem.