CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.268 | Topoisomerase; domain 3 |
|
1.10.268.10 | Topoisomerase, domain 3 |
Domain Context
CATH Clusters
| Superfamily | Topoisomerase, domain 3 |
| Functional Family | DNA gyrase subunit A |
Enzyme Information
| 5.6.2.3 |
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt P0AES5
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.
|
UniProtKB Entries (2)
| P0AES5 |
GYRA_SHIFL
Shigella flexneri
DNA gyrase subunit A
|
| Q84B82 |
Q84B82_ALIFS
Aliivibrio fischeri
CcdB
|
PDB Structure
| PDB | 4ELY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Alternative interactions define gyrase specificity in the CcdB family.
Mol.Microbiol.
|
