CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | UDP-glucose 6-dehydrogenase |
Enzyme Information
| 1.1.1.22 |
UDP-glucose 6-dehydrogenase.
based on mapping to UniProt O60701
UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH.
-!- Also acts on UDP-2-deoxyglucose.
|
UniProtKB Entries (1)
| O60701 |
UGDH_HUMAN
Homo sapiens
UDP-glucose 6-dehydrogenase
|
PDB Structure
| PDB | 4EDF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Cofactor binding triggers a molecular switch to allosterically activate human UDP-{alpha}-D-glucose 6-dehydrogenase.
Biochemistry
|