CATH Domain 4eakA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.310	TATA-Binding Protein
	3.30.310.80	Kinase associated domain 1, KA1

Domain Context

CATH Clusters

Superfamily	Kinase associated domain 1, KA1
Functional Family	Non-specific serine/threonine protein kinase

Enzyme Information

2.7.11.26	[Tau protein] kinase. based on mapping to UniProt P54645 ATP + [tau protein] = ADP + [tau protein] phosphate. -!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC 2.7.1.135.
2.7.11.31	[Hydroxymethylglutaryl-CoA reductase (NADPH)] kinase. based on mapping to UniProt P54645 ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate. -!- Activated by AMP. -!- EC 1.1.1.34 is inactivated by the phosphorylation of the enzyme protein. -!- Histones can also act as acceptors. -!- Can also phosphorylate EC 6.4.1.2 and EC 3.1.1.79. -!- Thr-172 within the catalytic subunit (alpha-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase. -!- GTP can act instead of ATP. -!- Formerly EC 2.7.1.109.
2.7.11.27	[Acetyl-CoA carboxylase] kinase. based on mapping to UniProt P54645 ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate. -!- Phosphorylates and inactivates EC 6.4.1.2, which can be dephosphorylated and reactivated by EC 3.1.3.17. -!- More active toward the dimeric form of acetyl-CoA carboxylase than the polymeric form. -!- Phosphorylates serine residues. -!- Formerly EC 2.7.1.111 and EC 2.7.1.128.
2.7.11.1	Non-specific serine/threonine protein kinase. based on mapping to UniProt P54645 ATP + a protein = ADP + a phosphoprotein. -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

AAKG1_RAT

Rattus norvegicus

5'-AMP-activated protein kinase subunit gamma-1

PDB Structure

PDB	4EAK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	AMP-activated protein kinase undergoes nucleotide-dependent conformational changes Chen, L., Wang, J., Zhang, Y.-Y., Yan, S.F., Neumann, D., Schlattner, U., Wang, Z.-X., Wu, J.-W. Nat.Struct.Mol.Biol.