CATH Domain 4e80A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.460	Beta Polymerase; domain 2
	3.30.460.10	Beta Polymerase, domain 2

Domain Context

CATH Clusters

Superfamily	Beta Polymerase, domain 2
Functional Family	Terminal uridylyltransferase cid1

Enzyme Information

2.7.7.19

Polynucleotide adenylyltransferase.

based on mapping to UniProt O13833

ATP + RNA(n) = diphosphate + RNA(n+1).

-!- Also acts slowly with CTP. -!- Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- The primer, depending on the source of the enzyme, may be an RNA or DNA fragment or oligo(A) bearing a 3'-OH terminal group. -!- See also EC 2.7.7.6.

2.7.7.52

RNA uridylyltransferase.

based on mapping to UniProt O13833

UTP + RNA(n) = diphosphate + RNA(n+1).

-!- Requires an oligoribonucleotide or polyribonucleotide with a free terminal 3'-OH as a primer.

UniProtKB Entries (1)

O13833

CID1_SCHPO

Schizosaccharomyces pombe 972h-

Terminal uridylyltransferase cid1

PDB Structure

PDB	4E80
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferase. Yates, L.A., Fleurdepine, S., Rissland, O.S., De Colibus, L., Harlos, K., Norbury, C.J., Gilbert, R.J. Nat.Struct.Mol.Biol.