CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.340 | Endonuclease III; domain 1 | |
1.10.340.70 |
Domain Context
CATH Clusters
Superfamily | 1.10.340.70 |
Functional Family | Pro-Pol polyprotein |
Enzyme Information
3.1.-.- |
Acting on ester bonds.
based on mapping to UniProt P14350
|
3.4.23.- |
Aspartic endopeptidases.
based on mapping to UniProt P14350
|
2.7.7.49 |
RNA-directed DNA polymerase.
based on mapping to UniProt P14350
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
|
3.1.26.4 |
Ribonuclease H.
based on mapping to UniProt P14350
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- Acts on RNA-DNA hybrids.
|
2.7.7.7 |
DNA-directed DNA polymerase.
based on mapping to UniProt P14350
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
|
2.7.7.- |
Nucleotidyltransferases.
based on mapping to UniProt P14350
|
UniProtKB Entries (1)
P14350 |
POL_FOAMV
Human spumaretrovirus
Pro-Pol polyprotein
|
PDB Structure
PDB | 4E7K |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
3'-Processing and strand transfer catalysed by retroviral integrase in crystallo.
Embo J.
|