CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.10 | Roll |
|
3.10.20 | Ubiquitin-like (UB roll) |
|
3.10.20.90 | Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 |
Domain Context
CATH Clusters
| Superfamily | Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 |
| Functional Family | Inhibitor of nuclear factor kappa B kinase subunit beta |
Enzyme Information
| 2.7.11.10 |
I-kappa-B kinase.
based on mapping to UniProt O14920
ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].
-!- Phosphorylates I-kappa-B proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. -!- Subsequent degradation of the I-kappa-B complex (IKK) activates NF-kappa-B, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. -!- If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably. -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (1)
| O14920 |
IKKB_HUMAN
Homo sapiens
Inhibitor of nuclear factor kappa-B kinase subunit beta
|
PDB Structure
| PDB | 4E3C |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
X-ray crystal structure of human IKK2 in an active conformation
Plos.Biol.
|
