CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.510 | Transferase(Phosphotransferase); domain 1 |
|
1.10.510.10 | Transferase(Phosphotransferase) domain 1 |
Domain Context
CATH Clusters
| Superfamily | Transferase(Phosphotransferase) domain 1 |
| Functional Family | Inhibitor of nuclear factor kappa-B kinase subunit beta |
Enzyme Information
| 2.7.11.10 |
I-kappa-B kinase.
based on mapping to UniProt O14920
ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].
-!- Phosphorylates I-kappa-B proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. -!- Subsequent degradation of the I-kappa-B complex (IKK) activates NF-kappa-B, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. -!- If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably. -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (1)
| O14920 |
IKKB_HUMAN
Homo sapiens
Inhibitor of nuclear factor kappa-B kinase subunit beta
|
PDB Structure
| PDB | 4E3C |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
X-ray crystal structure of human IKK2 in an active conformation
Plos.Biol.
|
