CATH Domain 4e20A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Tyrosine-protein kinase JAK2

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt Q9R117

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q9R117

TYK2_MOUSE

Mus musculus

Non-receptor tyrosine-protein kinase TYK2

PDB Structure

PDB	4E20
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor. Argiriadi, M.A., Goedken, E.R., Banach, D., Borhani, D.W., Burchat, A., Dixon, R.W., Marcotte, D., Overmeyer, G., Pivorunas, V., Sadhukhan, R., Sousa, S., Moore, N.S., Tomlinson, M., Voss, J., Wang, L., Wishart, N., Woller, K., Talanian, R.V. Bmc Struct.Biol.