CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.200 | Phosphorylase Kinase; domain 1 | |
3.30.200.20 | Phosphorylase Kinase; domain 1 |
Domain Context
CATH Clusters
Superfamily | Phosphorylase Kinase; domain 1 |
Functional Family | Tyrosine-protein kinase |
Enzyme Information
2.7.10.2 |
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q9R117
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.
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UniProtKB Entries (1)
Q9R117 |
TYK2_MOUSE
Mus musculus
Non-receptor tyrosine-protein kinase TYK2
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PDB Structure
PDB | 4E20 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor.
Bmc Struct.Biol.
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