CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.1640 | Multidrug efflux transporter AcrB transmembrane fold |
|
1.20.1640.10 | Multidrug efflux transporter AcrB transmembrane domain |
Domain Context
CATH Clusters
| Superfamily | Multidrug efflux transporter AcrB transmembrane domain |
| Functional Family | Efflux pump membrane transporter |
Enzyme Information
UniProtKB Entries (1)
| P31224 |
ACRB_ECOLI
Escherichia coli K-12
Multidrug efflux pump subunit AcrB
|
PDB Structure
| PDB | 4DX7 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop.
Proc.Natl.Acad.Sci.USA
|