CATH Domain 4dx7B04

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.2090	Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains
	3.30.2090.10	Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains

Domain Context

CATH Clusters

Superfamily	Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains
Functional Family	Efflux pump membrane transporter

Enzyme Information

UniProtKB Entries (1)

ACRB_ECOLI

Escherichia coli K-12

Multidrug efflux pump subunit AcrB

PDB Structure

PDB	4DX7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop. Eicher, T., Cha, H.J., Seeger, M.A., Brandstatter, L., El-Delik, J., Bohnert, J.A., Kern, W.V., Verrey, F., Grutter, M.G., Diederichs, K., Pos, K.M. Proc.Natl.Acad.Sci.USA