CATH Domain 4dv8A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.2030	Anthrax toxin lethal factor, domain 3, chain A
	1.10.2030.10	Anthrax toxin lethal factor, domain 3, chain A

Domain Context

CATH Clusters

Superfamily	Anthrax toxin lethal factor, domain 3, chain A
Functional Family

Enzyme Information

3.4.24.83

Anthrax lethal factor endopeptidase.

based on mapping to UniProt P15917

Preferred amino acids around the cleavage site can be denoted BBBBxHx-|-H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases.

-!- From the bacterium Bacilus anthracis that causes anthrax. -!- One of three proteins that are collectively termed anthrax toxin. -!- Cleaves several MAP kinase kinases near their N-termini, preventing them from phosphorylating the downstream mitogen-activated protein kinases. -!- Belongs to peptidase family M34.

UniProtKB Entries (1)

P15917

LEF_BACAN

Bacillus anthracis

Lethal factor

PDB Structure

PDB	4DV8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain. Jiao, G.S., Kim, S., Moayeri, M., Crown, D., Thai, A., Cregar-Hernandez, L., McKasson, L., Sankaran, B., Lehrer, A., Wong, T., Johns, L., Margosiak, S.A., Leppla, S.H., Johnson, A.T. Bioorg.Med.Chem.Lett.