CATH Domain 4durA07

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.7

Plasmin.

based on mapping to UniProt P00747

Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.

-!- Formed from plasminogen by proteolysis which results in multiple forms of the active plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.14.

UniProtKB Entries (1)

P00747

PLMN_HUMAN

Homo sapiens

Plasminogen

PDB Structure

PDB	4DUR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The X-ray crystal structure of full-length human plasminogen Law, R.H.P., Caradoc-Davies, T., Cowieson, N., Horvath, A.J., Quek, A.J., Encarnacao, J.A., Steer, D., Cowan, A., Zhang, Q., Lu, B.G.C., Pike, R.N., Smith, A.I., Coughlin, P.B., Whisstock, J.C. Cell Rep