CATH Domain 4durA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.50	3-Layer(bba) Sandwich
	3.50.4	Hepatocyte Growth Factor
	3.50.4.10	Hepatocyte Growth Factor

Domain Context

CATH Clusters

Superfamily	Hepatocyte Growth Factor
Functional Family	Plasminogen

Enzyme Information

3.4.21.7

Plasmin.

based on mapping to UniProt P00747

Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.

-!- Formed from plasminogen by proteolysis which results in multiple forms of the active plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.14.

UniProtKB Entries (1)

P00747

PLMN_HUMAN

Homo sapiens

Plasminogen

PDB Structure

PDB	4DUR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The X-ray crystal structure of full-length human plasminogen Law, R.H.P., Caradoc-Davies, T., Cowieson, N., Horvath, A.J., Quek, A.J., Encarnacao, J.A., Steer, D., Cowan, A., Zhang, Q., Lu, B.G.C., Pike, R.N., Smith, A.I., Coughlin, P.B., Whisstock, J.C. Cell Rep