CATH Domain 4dpdA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.572	Thymidylate Synthase; Chain A
	3.30.572.10	Thymidylate synthase/dCMP hydroxymethylase domain

Domain Context

CATH Clusters

Superfamily	Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family	Bifunctional dihydrofolate reductase-thymidylate synthase

Enzyme Information

UniProtKB Entries (1)

A7UD81_PLAFA

Plasmodium falciparum

Bifunctional dihydrofolate reductase-thymidylate synthase

PDB Structure

PDB	4DPD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target Yuthavong, Y., Tarnchompoo, B., Vilaivan, T., Chitnumsub, P., Kamchonwongpaisan, S., Charman, S.A., McLennan, D.N., White, K.L., Vivas, L., Bongard, E., Thongphanchang, C., Taweechai, S., Vanichtanankul, J., Rattanajak, R., Arwon, U., Fantauzzi, P., Yuvaniyama, J., Charman, W.N., Matthews, D. Proc.Natl.Acad.Sci.USA