CATH Domain 4do3A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1300	Amidase signature (AS) enzymes
	3.90.1300.10	Amidase signature (AS) domain

Domain Context

CATH Clusters

Superfamily	Amidase signature (AS) domain
Functional Family	Fatty-acid amide hydrolase 1

Enzyme Information

3.5.1.99

Fatty acid amide hydrolase.

based on mapping to UniProt P97612

(1) Anandamide + H(2)O = arachidonic acid + ethanolamine. (2) Oleamide + H(2)O = oleic acid + NH(3).

-!- Integral membrane protein, the enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide, occurs in mammalia. -!- Formerly EC 3.5.1.n2.

UniProtKB Entries (1)

P97612

FAAH1_RAT

Rattus norvegicus

Fatty-acid amide hydrolase 1

PDB Structure

PDB	4DO3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A Binding Site for Nonsteroidal Anti-inflammatory Drugs in Fatty Acid Amide Hydrolase. Bertolacci, L., Romeo, E., Veronesi, M., Magotti, P., Albani, C., Dionisi, M., Lambruschini, C., Scarpelli, R., Cavalli, A., De Vivo, M., Piomelli, D., Garau, G. J.Am.Chem.Soc.