CATH Classification

Domain Context

CATH Clusters

Superfamily Terpene synthase, N-terminal domain
Functional Family Isoprene synthase, chloroplastic

Enzyme Information

4.2.3.61
5-epiaristolochene synthase.
based on mapping to UniProt Q40577
(2E,6E)-farnesyl diphosphate = (+)-5-epiaristolochene + diphosphate.
-!- Initial cyclization gives (+)-germacrene A in an enzyme bound form which is not released to the medium.

UniProtKB Entries (1)

Q40577
5EAS_TOBAC
Nicotiana tabacum
5-epi-aristolochene synthase

PDB Structure

PDB 4DI5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Co-crystal structure of WT 5-epi-Aristolochene synthase from Nicotiana tobaccum with geraniline
Noel, J.P., Starks, C., Crenshaw, C.M.
To be Published
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