CATH Domain 4dgbA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.100	Cyclophilin
	2.40.100.10	Cyclophilin-like

Domain Context

CATH Clusters

Superfamily	Cyclophilin-like
Functional Family	Peptidyl-prolyl cis-trans isomerase A

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt P62940

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (2)

P04590	GAG_HV2RO Human immunodeficiency virus type 2 (ISOLATE ROD) Gag polyprotein
P62940	PPIA_MACMU Macaca mulatta Peptidyl-prolyl cis-trans isomerase A

PDB Structure

PDB	4DGB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Diverse HIV viruses are targeted by a conformationally dynamic antiviral. Caines, M.E., Bichel, K., Price, A.J., McEwan, W.A., Towers, G.J., Willett, B.J., Freund, S.M., James, L.C. Nat.Struct.Mol.Biol.