CATH Classification
Level | CATH Code | Description |
---|---|---|
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2 | Mainly Beta |
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2.40 | Beta Barrel |
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2.40.100 | Cyclophilin |
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2.40.100.10 | Cyclophilin-like |
Domain Context
CATH Clusters
Superfamily | Cyclophilin-like |
Functional Family | Peptidyl-prolyl cis-trans isomerase A |
Enzyme Information
5.2.1.8 |
Peptidylprolyl isomerase.
based on mapping to UniProt P62940
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.
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UniProtKB Entries (2)
P12497 |
POL_HV1N5
Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)
Gag-Pol polyprotein
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P62940 |
PPIA_MACMU
Macaca mulatta
Peptidyl-prolyl cis-trans isomerase A
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PDB Structure
PDB | 4DGA |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Diverse HIV viruses are targeted by a conformationally dynamic antiviral.
Nat.Struct.Mol.Biol.
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