CATH Domain 4d8dA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.30	SH3 type barrels.
	2.30.30.40	SH3 Domains

Domain Context

CATH Clusters

Superfamily	SH3 Domains
Functional Family	Tyrosine-protein kinase Fyn

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P06241

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (2)

P03406	NEF_HV1BR Human immunodeficiency virus type 1 (BRU ISOLATE) Protein Nef
P06241	FYN_HUMAN Homo sapiens Tyrosine-protein kinase Fyn

PDB Structure

PDB	4D8D
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	SH3 domain specificity Lugani, A., Lin, C.C., Shi, X., Hoh, F., Ponchon, L., Ktori, C., Dumas, C., Ladbury, J.E., Collette, Y., Morelli, X., Arold, S.T. To be Published