CATH Domain 4d7hA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1230	Bovine Endothelial Nitric Oxide Synthase Heme Domain; Chain: A,domain 3
	3.90.1230.10	Nitric Oxide Synthase; Chain A, domain 3

Domain Context

CATH Clusters

Superfamily	Nitric Oxide Synthase; Chain A, domain 3
Functional Family	Nitric oxide synthase, brain

Enzyme Information

1.14.14.47

Nitric-oxide synthase (flavodoxin).

based on mapping to UniProt O34453

2 L-arginine + 3 reduced flavodoxin + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 oxidized flavodoxin + 4 H(2)O.

-!- The enzyme, found in bacteria and archaea, consist of only an oxygenase domain and functions together with bacterial ferredoxins or flavodoxins. -!- The orthologous enzymes from plants and animals also contain a reductase domain and use only NADPH as the electron donor (cf. EC 1.14.13.39). -!- Formerly EC 1.14.13.165.

UniProtKB Entries (1)

O34453

NOSO_BACSU

Bacillus subtilis subsp. subtilis str. 168

Nitric oxide synthase oxygenase

PDB Structure

PDB	4D7H
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus Aureus Holden, J.K., Kang, S., Beasley, F.C., Cinelli, M.A., Li, H., Roy, S.G., Dejam, D., Edinger, A.L., Nizet, V., Silverman, R.B., Poulos, T.L. Chem.Biol.