CATH Domain 4d3uA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1230	Bovine Endothelial Nitric Oxide Synthase Heme Domain; Chain: A,domain 3
	3.90.1230.10	Nitric Oxide Synthase; Chain A, domain 3

Domain Context

CATH Clusters

Superfamily	Nitric Oxide Synthase; Chain A, domain 3
Functional Family	Nitric oxide synthase, brain

Enzyme Information

1.14.14.47

Nitric-oxide synthase (flavodoxin).

based on mapping to UniProt O34453

2 L-arginine + 3 reduced flavodoxin + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 oxidized flavodoxin + 4 H(2)O.

-!- The enzyme, found in bacteria and archaea, consist of only an oxygenase domain and functions together with bacterial ferredoxins or flavodoxins. -!- The orthologous enzymes from plants and animals also contain a reductase domain and use only NADPH as the electron donor (cf. EC 1.14.13.39). -!- Formerly EC 1.14.13.165.

UniProtKB Entries (1)

O34453

NOSO_BACSU

Bacillus subtilis subsp. subtilis str. 168

Nitric oxide synthase oxygenase

PDB Structure

PDB	4D3U
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors. Holden, J.K., Kang, S., Hollingsworth, S.A., Li, H., Lim, N., Chen, S., Huang, H., Xue, F., Tang, W., Silverman, R.B., Poulos, T.L. J.Med.Chem.