CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.90 | Alpha-Beta Complex |
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3.90.440 | Nitric Oxide Synthase;Heme Domain; Chain A, domain 2 |
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3.90.440.10 | Nitric Oxide Synthase;Heme Domain;Chain A domain 2 |
Domain Context
CATH Clusters
Superfamily | Nitric Oxide Synthase;Heme Domain;Chain A domain 2 |
Functional Family |
Enzyme Information
1.14.13.39 |
Nitric-oxide synthase (NADPH).
based on mapping to UniProt P29476
2 L-arginine + 3 NADPH + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O.
-!- The enzyme consists of linked oxygenase and reductase domains. -!- The eukaryotic enzyme binds FAD, FMN, heme (iron protoporphyrin IX) and tetrahydrobiopterin, and its two domains are linked via a regulatory calmodulin-binding domain. -!- Upon calcium-induced calmodulin binding, the reductase and oxygenase domains form a complex, allowing electrons to flow from NADPH via FAD and FMN to the active center. -!- The reductase domain of the enzyme from the bacterium Sorangium cellulosum utilizes a [2Fe-2S] cluster to transfer the electrons from NADPH to the active center. -!- Cf. EC 1.14.14.47.
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UniProtKB Entries (1)
P29476 |
NOS1_RAT
Rattus norvegicus
Nitric oxide synthase, brain
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PDB Structure
PDB | 4D32 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase.
J.Med.Chem.
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