CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.590 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like |
Domain Context
CATH Clusters
| Superfamily | Alpha-ketoglutarate-dependent dioxygenase AlkB-like |
| Functional Family | FTO, alpha-ketoglutarate dependent dioxygenase |
Enzyme Information
| 1.14.11.53 |
mRNA N(6)-methyladenine demethylase.
based on mapping to UniProt Q9C0B1
N(6)-methyladenosine in mRNA + 2-oxoglutarate + O(2) = adenosine in mRNA + formaldehyde + succinate + CO(2).
-!- Catalyzes oxidative demethylation of mRNA N(6)-methyladenine. -!- The FTO enzyme from human can also demethylate N(3)-methylthymine from single stranded DNA and N(3)-methyluridine from single stranded RNA with low activity.
|
| 1.14.11.- |
With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.
based on mapping to UniProt Q9C0B1
|
UniProtKB Entries (1)
| Q9C0B1 |
FTO_HUMAN
Homo sapiens
Alpha-ketoglutarate-dependent dioxygenase FTO
|
PDB Structure
| PDB | 4CXW |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor ofN6-methyladenosine demethylase FTO.
Chem Sci
|
