CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.1380 | Neutral endopeptidase; domain 2 | |
1.10.1380.10 | Neutral endopeptidase , domain2 |
Domain Context
CATH Clusters
Superfamily | Neutral endopeptidase , domain2 |
Functional Family | Membrane metalloendopeptidase |
Enzyme Information
3.4.24.11 |
Neprilysin.
based on mapping to UniProt P08473
Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.
-!- A membrane-bound glycoprotein widely distributed in animal tissues. -!- Inhibited by phosphoramidon and thiorphan. -!- Belongs to peptidase family M13.
|
UniProtKB Entries (1)
P08473 |
NEP_HUMAN
Homo sapiens
Neprilysin
|
PDB Structure
PDB | 4CTH |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Engineering Neprilysin Activity and Specificity to Create a Novel Therapeutic for Alzheimer'S Disease.
Plos One
|