CATH Classification
Level | CATH Code | Description |
---|---|---|
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2 | Mainly Beta |
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2.40 | Beta Barrel |
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2.40.10 | Thrombin, subunit H |
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2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
Superfamily | Trypsin-like serine proteases |
Functional Family | Coagulation factor XI |
Enzyme Information
3.4.21.27 |
Coagulation factor XIa.
based on mapping to UniProt P03951
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
-!- The proenzyme XI is activated by EC 3.4.21.38. -!- Belongs to peptidase family S1.
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UniProtKB Entries (1)
P03951 |
FA11_HUMAN
Homo sapiens
Coagulation factor XI
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PDB Structure
PDB | 4CRG |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Creating Novel Activated Factor Xi Inhibitors Through Fragment Based Lead Generation and Structure Aided Drug Design.
Plos One
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