CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.60 | 4-Layer Sandwich |
|
3.60.10 | Deoxyribonuclease I; Chain A |
|
3.60.10.10 | Endonuclease/exonuclease/phosphatase |
Domain Context
CATH Clusters
| Superfamily | Endonuclease/exonuclease/phosphatase |
| Functional Family | Type II inositol 1,4,5-trisphosphate 5-phosphatase |
Enzyme Information
| 3.1.3.36 |
Phosphoinositide 5-phosphatase.
based on mapping to UniProt Q01968
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl- 1D-myo-inositol 4-phosphate + phosphate.
-!- These enzymes can also remove the 5-phosphate from Ins(1,4,5)P(3) and/or Ins(1,3,4,5)P(4). -!- They are a diverse family of enzymes, with differing abilities to catalyze two or more of the four reactions listed. -!- They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo. -!- All of them can use either or both of PtdIns(4,5)P(2) and PtdIns(3,4,5)P(3) as substrates; this is the main property that distinguishes them from EC 3.1.3.56.
|
UniProtKB Entries (1)
| Q01968 |
OCRL_HUMAN
Homo sapiens
Inositol polyphosphate 5-phosphatase OCRL-1
|
PDB Structure
| PDB | 4CMN |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases.
Structure
|
