CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | mRNA-capping enzyme catalytic subunit |
Enzyme Information
| 2.7.7.50 |
mRNA guanylyltransferase.
based on mapping to UniProt P04298
GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA.
-!- Can modify also synthetic poly(A) and poly(G) to form the structures m(7)G(5')pppAn and m(7)G(5')pppGn.
|
| 3.1.3.33 |
Polynucleotide 5'-phosphatase.
based on mapping to UniProt P04298
A 5'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate.
-!- Does not act on nucleoside monophosphates. -!- Induced in Escherichia coli by T-even phages.
|
| 2.1.1.56 |
mRNA (guanine-N(7)-)-methyltransferase.
based on mapping to UniProt P04298
S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA.
-!- Adds an N(7)-methylguanine cap to mRNA. -!- The nucleoside next to the terminal guanosine may be either guanosine or adenosine.
|
UniProtKB Entries (1)
| P04298 |
MCEL_VACCW
Vaccinia virus WR
MRNA-capping enzyme catalytic subunit
|
PDB Structure
| PDB | 4CKC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure of Vaccinia Virus Mrna Capping Enzyme Provides Insights Into the Mechanism and Evolution of the Capping Apparatus.
Structure
|
