CATH Classification
Level | CATH Code | Description |
---|---|---|
![]() |
2 | Mainly Beta |
![]() |
2.40 | Beta Barrel |
![]() |
2.40.10 | Thrombin, subunit H |
![]() |
2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
Superfamily | Trypsin-like serine proteases |
Functional Family |
Enzyme Information
3.4.21.46 |
Complement factor D.
based on mapping to UniProt P00746
Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.
-!- A component of the alternative pathway of complement activation. -!- This reaction is analogous to the activation of complement component C2 by activated complement subcomponent C1s. -!- Belongs to peptidase family S1.
|
UniProtKB Entries (1)
P00746 |
CFAD_HUMAN
Homo sapiens
Complement factor D
|
PDB Structure
PDB | 4CBN |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Ensemble Refinement Shows Conformational Flexibility in Crystal Structures of Human Complement Factor D
Acta Crystallogr.,Sect.D
|