CATH Classification

Domain Context

CATH Clusters

Superfamily 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Functional Family 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

Enzyme Information

4.6.1.12
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase.
based on mapping to UniProt P62368
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = 2-C-methyl- D-erythritol 2,4-cyclodiphosphate + CMP.
-!- Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.

UniProtKB Entries (1)

P62368
ISPF_PLAF7
Plasmodium falciparum 3D7
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

PDB Structure

PDB 4C81
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of Ispf from Plasmodium Falciparum and Burkholderia Cenocepacia: Comparisons Inform Antimicrobial Drug Target Assessment.
O Rourke, P.E., Kalinowska-Tluscik, J., Fyfe, P.K., Dawson, A., Hunter, W.N.
Bmc Struct.Biol.
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